Search results
Ketosis-prone diabetes (KPD) is an intermediate form of diabetes that has some characteristics of type 1 and some of type 2 diabetes. Type 1 diabetes involves autoimmune destruction of pancreatic beta cells which create insulin.
Ketone-prone diabetes or Flatbush diabetes is being increasingly recognized worldwide. It is typically seen in obese middle-aged men with a family history of Type 2 DM. Atypicality in the onset of age and gender variation is increasingly observed worldwide.
24 sty 2022 · Our report sheds light on the atypicality of presentation and summarizes the main diagnostic features of this rare form of diabetes. Increased awareness of this entity can facilitate early diagnosis and management.
22 sie 2023 · Ketosis-prone diabetes (KPD) comprises a group of diabetes syndromes characterized by severe beta cell dysfunction (manifested by presentation with DKA or unprovoked ketosis) and a variable clinical course.
2 paź 2018 · Major questions remain as to its pathogenesis and whether it is a unique type of diabetes or a subset of more severe type 2 diabetes with greater loss of insulin action in target tissues. This review summarizes the main clinical and mechanistic studies to improve the understanding of ketosis-prone (Flatbush) diabetes.
In 2002, Sobngwi et al. introduced the term “ketosis-prone diabetes” in a review of diabetes in West Africans. Ketosis-prone diabetes, also known as “Flatbush Diabetes”, has pathophysiology close to that of T2DM but initially exhibits signs and symptoms of T1DM ( 4 ).
Ketosis-prone type 2 DM, sometimes referred to as “Flatbush Diabetes” after a clinic in New York where it was first described, shares a similar pathophysiology as type 2 DM, but presents initially with signs and symptoms of type 1 DM (Balasubramanyam, Nalini, Hampe, & Maldonado, 2008).
