Search results
5 paź 2018 · Both WHO and the US Centers for Disease Control and Prevention (CDC) recommend a single 2 g dose of oral metronidazole or tinidazole as first-line treatment and a 7-day dose of oral metronidazole (400 mg or 500 mg twice daily for 7 days) as second-line treatment for Trichomonas vaginalis infections. 7,8 In most settings, metronidazole is used ...
Multidose oral metronidazole is more effective than single-dose treatment, particularly for women who are symptomatic or have a history of T. vaginalis (1120). Nitroimidazole-resistant trichomoniasis is concerning because few alternatives to standard therapy exist.
Single-dose versus 7-day-dose metronidazole for the treatment of trichomoniasis in women: an open-label, randomised controlled trial
Single-dose versus 7-day-dose metronidazole for the treatment of trichomoniasis in women: an open-label, randomised controlled trial
Multidose metronidazole has been found to be superior to single-dose metronidazole for the treatment of trichomoniasis in a randomised controlled trial done in women with HIV infection, 1 in a meta-analysis of published comparisons, 2 and in our randomised controlled trial done in women without HIV infection, published in The Lancet Infectious ...
Our finding adds to the evidence that 7 day-dose metronidazole is superior to single-dose for the treatment of trichomoniasis in women irrespective of BV status. These results can be used to refine treatment guidelines for trichomoniasis in HIV-uninfected women. Implications of all the available evidence
Two multi-centered randomized trials and a meta-analysis found that women receiving multi-dose MTZ were nearly half as likely to retest positive to T. vaginalis post-treatment compared to women receiving single-dose MTZ, indicating that multi-dose MTZ should be recommended over single-dose.
