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  1. 1 kwi 2022 · Heart failure remains a leading cause of morbidity and mortality globally. The 2022 heart failure guideline provides recommendations based on contemporary evidence for the treatment of these patients.

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  2. Fortunately, we now have a wealth of clinical trials to help us select the best management to improve the outcomes for people with HF; for many, it is now both preventable and treatable. This guideline provides practical, evidence-based recommendations.

  3. 8 mar 2024 · Sacubitril/valsartan is 1 of the “4 pillars” of medical care for HFrEF. The 2022 AHA/ACC/HFSA HF guideline 2 recommends sacubitril/valsartan as a Class I, Level of Evidence: A therapy to reduce the risk of HF hospitalization and CV mortality in patients with symptomatic chronic HFrEF (Figures 2 and 3, Table 2).

  4. 1 kwi 2022 · ARNi is now recommended as first-line RASi to reduce morbidity and mortality in HFrEF (Class of Recommendation 1a). ACEi is recommended when ARNi is not feasible, and ARB in those who are ACEi intolerant and when ARNi is not feasible.

  5. 12 wrz 2018 · Digoxin is recommended for worsening or severe heart failure with reduced ejection fraction despite first-line treatment for heart failure. Seek specialist advice before initiating. [2010, amended 2018]

  6. After a patient has been diagnosed with a type, stage, and class, treatment can be determined. First-line drug therapy for all patients with HFrEF should include an angiotensin-converting enzyme (ACE) inhibitor and beta blocker. 5 These medications have been shown to decrease morbidity and mortality. 5

  7. 24 wrz 2018 · Offer angiotensin converting enzyme (ACE) inhibitors and beta blockers as first line treatment for heart failure with reduced ejection fraction, and add mineralocorticoid receptor antagonist (MRA) if symptoms continue.

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