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2 gru 2020 · Here, we review current knowledge on the integrated molecular machinery of ferroptosis and describe how dysregulated ferroptosis is involved in cancer, neurodegeneration, tissue injury ...
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3 mar 2020 · This phenotype relies on HIF1A-mediated upregulation of fatty-acid-binding protein 3 (FABP3) and fatty-acid-binding protein 7 (FABP7), which promotes fatty-acid uptake and lipid storage, driving...
16 kwi 2020 · HIF1A, one of the major transcription factors regulating hypoxic response, plays a pro-survival role in ferroptosis through the upregulation of fatty acid binding protein 3 (FABP3, muscle and heart) and fatty acid binding protein 7 (FABP7, brain) for lipid storage (Yang et al., 2019a).
We characterize the contribution of autophagy to ferroptosis in human cancer cell lines and mouse tumor models. We show that “clockophagy,” the selective degradation of the core circadian clock protein ARNTL by autophagy, is critical for ferroptosis.
2 gru 2020 · Core molecular machinery and signaling regulation of ferroptosis. Ferroptosis can occur through two major pathways, the extrinsic or transporter-dependent pathway (e.g., decreased cysteine or glutamine uptake and increased iron uptake), and the intrinsic or enzyme-regulated pathway (e.g., the inhibition of GPX4).
26 sie 2020 · Lipid peroxidation is a hallmark of ferroptosis and is caused by a complex process of lipid metabolism, involving non-enzymatic Fenton reaction and enzymatic reaction pathways. Polyunsaturated fatty acids (PUFAs) are one of the main targets of lipid peroxidation.
HIF1A, one of the major transcription factors regulating hypoxic response, plays a pro-survival role in ferroptosis through the upregulation of fatty acid binding protein 3 (FABP3, muscle and heart) and fatty acid binding protein 7 (FABP7, brain) for lipid storage (Yang et al., 2019a).
