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5 sty 2023 · Based on a longitudinal analysis of mutational prevalence globally, we found an expanding repertoire of Spike protein deletions proximal to an antigenic supersite in the N-terminal domain that...
13 gru 2023 · SARS-CoV-2 mutations, such as S:D614G, are a clear example where variants with specific alterations conferring selective advantage, rapidly increase their frequency and become dominant .
Understanding the genetics of SARS-CoV-2 may open some new avenues for the development of more effective and safer targeted therapies and even new generations of vaccines for this highly mutable coronavirus.
A deep understanding of different diagnosis methods for COVID-19 could help researchers make an optimal choice in detecting COVID-19 at different symptom stages. In this review, we summarize and evaluate the latest developments in current nucleic acid detection methods for SARS-CoV-2.
Out of total mutations 3328, 1344 are synonymous mutations 57 are deletion mutations, 2 are insertion mutations, 7 are frame shift deletion mutations, and 13 are stop-gained (Koyama et al. 2020). The most frequent mutations E191G, G76S, K61N, V259L, T176I, L140V, T269M and V88L are in the ORF region.
14 gru 2020 · The described research techniques provide the basic framework to set up SHERLOCK-based COVID-19 tests by using paper strips.
17 cze 2022 · SARS-CoV-2 variant mutation in spike protein appeared in epidemiological and clinical aspects of the COVID-19 pandemic . The spike mutations in the Alpha variant are consist of the substitution mutation in RBD, including N501Y, P681H, and deletion mutations in NTD at positions 69–70 and 144.
