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  1. Hormones from the mother (maternal hormones) are some of the chemicals that pass through the placenta into the baby's blood during pregnancy. These hormones can affect the baby. For example, pregnant women produce high levels of the hormone estrogen. This causes breast enlargement in the mother.

  2. Premature thelarche is enlargement of the breasts in infant girls. Most often, breast enlargement is the only abnormality. It is occasionally the first sign of early (precocious) puberty. This is more likely if the breasts become enlarged after ages 2 to 3.

  3. 4 mar 2021 · Redundant or fimbriated hymens that appear to be sleeve-like or ruffled are common in newborns because of maternal estrogen effects. The crescentic shape becomes the most common shape around the age of 4 years in the prepubertal female [ 5 ].

  4. Hormones from the mother (maternal hormones) are some of the chemicals that pass through the placenta into the baby's blood during pregnancy. These hormones can affect the baby. For example, pregnant women produce high levels of the hormone estrogen. This causes breast enlargement in the mother.

  5. As a girl reaches puberty, the first visible signs of breast development start to show. When the ovaries start to produce and release (secrete) estrogen, fat in the connective tissue starts to build up.

  6. Darkened (pigmented) areolae differentiated precocious puberty from transient neonatal breast hypertrophy due to transplacental estrogen in an infant girl with congenital hypothalamic hamartoma (8). Acanthosis nigricans can be associated with estrogen excess.

  7. As a girl approaches puberty, the first outward signs of breast development begin to appear. When the ovaries start to secrete estrogen, fat in the connective tissue begins to accumulate causing the breasts to enlarge. The duct system also begins to grow.

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