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Eosinopenia is defined as an absolute eosinophil count of less than 0.09 × 10 9 /L and can be difficult to detect because the reference interval is low. Eosinopenia often accompanies other cytopenias in conditions that result in marrow hypoplasia, specifically involving leukocytes.
Eosinopenia is associated with several disease states and conditions, including inflammation and sepsis, endogenous catecholamines, and use of glucocorticoids. [1] There are also medications that deliberately target eosinophils in order to treat eosinophil-mediated diseases, causing drug-induced eosinopenia.
Data on the effects of eosinopenia in humans comes primarily from monoclonal antibodies developed for the treatment of eosinophil-mediated diseases, three of which have received marketing approval: mepolizumab, reslizumab, and benralizumab.
24 maj 2021 · Sepsis is a life-threatening and time-critical medical emergency; therefore, the early diagnosis of sepsis is essential to timely treatment and favorable outcomes for patients susceptible to sepsis. Eosinopenia has been identified as a potential biomarker of sepsis in the past decade.
16 mar 2021 · While eosinopenia has been identified as a factor that may facilitate disease diagnosis and determine prognosis, this finding is neither definitive nor pathognomonic for COVID-19.
3 mar 2011 · As a cheap test for early identification of critically ill patients at high risk of mortality on admission to ICU, eosinopenia might aid physicians in their initial decisions, and help to identify patients who may require more aggressive diagnostic and therapeutic interventions.
Abstract. Background and Aim: Viral pneumonia is the most relevant clinical presentation of COVID- 19 which may lead to severe acute respiratory syndrome and even death. Eosinopenia was often noticed in patients with COVID- 19 pneumonia, but its role is poorly investigated.
