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Eosinopenia is associated with several disease states and conditions, including inflammation and sepsis, endogenous catecholamines, and use of glucocorticoids. [1] There are also medications that deliberately target eosinophils in order to treat eosinophil-mediated diseases, causing drug-induced eosinopenia.
The most common cause of hypereosinophilia in our pediatric cohort was secondary (reactive) hypereosinophilia. Atopic dermatitis, graft-versus-host disease, sickle cell disease, and parasitic infection were the most common disease entities associated with hypereosinophilia.
14 cze 2022 · A total of 149 children were included in which 7.4% (11) cases with eosinopenia and 52.3% (78) cases with sepsis. Septic patients with eosinopenia had a mortality rate 33.3% less than patients without eosinopenia at 43.2%.
Eosinopenia is defined as an absolute eosinophil count of less than 0.09 × 10 9 /L and can be difficult to detect because the reference interval is low. Eosinopenia often accompanies other cytopenias in conditions that result in marrow hypoplasia, specifically involving leukocytes.
24 maj 2021 · Our findings suggested that Eosinopenia has a high incidence in sepsis but has no superiority in comparison with conventional biomarkers for diagnosis of sepsis. However, eosinopenia can still be used in clinical diagnosis for sepsis as a simple, convenient, fast and inexpensive biomarker.
Eosinopenia, a biomarker for infection, has recently been shown to be a predictor of adult mortality in the intensive care unit (ICU). Our study assessed the usefulness of eosinopenia as a mortality and an infection biomarker in the pediatric ICU (PICU).
The presence of eosinopenia at the ICU admission can be a useful biomarker for mortality in children, but is not useful as a biomarker for infection. Key Words: Biomarkers; Child; Eosinophils; Infection; Intensive Care Units; Prognosis.
