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Mesenchymal stem cell-derived signaling and growth factors obtained by platelets influence hair growth through cellular proliferation to prolong the anagen phase (FGF-7), induce cell growth (ERK activation), stimulate hair follicle development (β-catenin), and suppress apoptotic cues (Bcl-2 release and Akt activation).
Human ESCs (hESCs) were activated to first create neural cells and then into hair-inducing DP-like cells in culture. hESC-derived DP-like cells express markers typically found in adult human DP cells and are able to encourage the growth of hair follicles when transplanted under the skin of mice.
1 cze 2024 · Induced pluripotent stem cells (iPSCs) are a promising avenue for hair follicle regeneration. This review explores current iPSC-based approaches and highlights their potential applications and challenges in hair restoration.
1 sty 2023 · PS cells such as embryonic stem (ES) cells and iPSCs have the capacity to self-renew and to develop into every cell of the adult body. Manufacturing a hair organoid using PS cells was recently succeeded in, and can be used as a screening tool for new drug development.
15 sie 2020 · Stem cell-derived CM is widely studied as hair regenerative medicine (Table 1). For instance, adipose-derived stem cell-CM (ADSC-CM) stimulates hair growth through the combined effects of diverse bioactive factors.
1 sty 2019 · Stem cells may have potential as a treatment for regenerating hair. Initially, methods to obtain stem cells have concentrated on isolating the primary cells from the tissue of interest through...
Stem cell-based therapies have recently received lots of attention as potential novel treatments that focus on reactivating hair follicle stem cells and in this way enhance hair follicle growth, regeneration and development.
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