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We evaluated EGFR expression at protein and mRNA levels in canine intestinal adenocarcinomas using immunohistochemistry (IHC) and RNA in situ hybridization (RNA-ISH). We also investigated the mutation status of EGFR, KRAS, and BRAF to aid the development of anti-EGFR agents for canine intestinal adenocarcinoma.
15 sty 2014 · Epidermal growth factor receptor (EGFR or HER-1) and its analog c-erbB-2 (HER-2) are protein tyrosine kinases correlated with prognosis and response to therapy in a variety of human cancers. KRAS mediates the transduction of signals between EGFR and the nucleus, and its mutation has been identified as a predictor of resistance to anti-EGFR drugs.
30 kwi 2021 · The EGFR, KRAS, and BRAF genes showed wild-type sequences at the mutation hot spots in all 13 specimens. Thus, EGFR might serve as a promising diagnostic marker in canine intestinal adenocarcinoma, and further studies would be needed to develop EGFR-targeted anticancer therapies.
20 lip 2024 · The observed NKX2-1 co-alteration pattern is supportive of the proposed differential functional significance of NKX2-1 in EGFR and KRAS mutated non-Sq NSCLC 32.
15 sty 2014 · KRAS gene was wild type in 18 cases, whereas one mucinous carcinoma harboured a point mutation at codon 12 (G12R). EGFR and HER-2 may be promising prognostic and therapeutic targets in canine gastric epithelial neoplasms.
19 sty 2023 · BRAF mutant tumors had a better prognosis when treated with lapatinib (EGFR and ERBB2 inhibitor) (OS HR 0.10, P = 0.02) and ARID1A with trametinib (MEK1/2 inhibitor) (OS HR 0.08, P = 0.02...
14 lis 2019 · Epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene homolog (K-RAS) are two of the main significant biomarkers for the management of NSCLC. Mutations in these genes were associated with development and response to therapies.
