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  1. journals.sagepub.com › doi › pdfEGFR Overexpression and Sequence Analysis of KRAS, BRAF, and EGFR...

    We evaluated EGFR expression at protein and mRNA levels in canine intestinal adenocarcinomas using immunohistochemistry (IHC) and RNA in situ hybridization (RNA-ISH). We also investigated the mutation status of EGFR, KRAS, and BRAF to aid the development of anti-EGFR agents for canine intestinal adenocarcinoma.

  2. www.ncbi.nlm.nih.gov › pmc › articlesEGFR, HER-2 and KRAS in Canine Gastric Epithelial Tumors: A...

    15 sty 2014 · Epidermal growth factor receptor (EGFR or HER-1) and its analog c-erbB-2 (HER-2) are protein tyrosine kinases correlated with prognosis and response to therapy in a variety of human cancers. KRAS mediates the transduction of signals between EGFR and the nucleus, and its mutation has been identified as a predictor of resistance to anti-EGFR drugs.

  3. pmc.ncbi.nlm.nih.gov › articles › PMC6036498Association between EGFR/KRAS mutation and expression of VEGFA,...

    EGFR/KRAS mutations and the association with the clinicopathological characteristics of patients with lung adenocarcinoma. Among the total 204 cases, 104 (51.0%) mutated EGFR and 19 (9.3%) mutated KRAS (exon 2) were identified. Of the 104 cases, there were 44 exon-19 mutations, 13 exon-20 mutations and 47 exon-21 mutations.

  4. pubmed.ncbi.nlm.nih.gov › 24454858EGFR, HER-2 and KRAS in canine gastric epithelial tumors: a ... -...

    15 sty 2014 · A total of 19 canine gastric epithelial neoplasms (5 adenomas and 14 carcinomas) were retrospectively evaluated for EGFR/HER-2 immunohistochemical expression and KRAS mutational status. Five (35.7%) carcinomas were classified as intestinal-type and 9 (64.3%) as diffuse-type.

  5. pubmed.ncbi.nlm.nih.gov › 33926328EGFR Overexpression and Sequence Analysis of KRAS, BRAF, and EGFR...

    30 kwi 2021 · The EGFR, KRAS, and BRAF genes showed wild-type sequences at the mutation hot spots in all 13 specimens. Thus, EGFR might serve as a promising diagnostic marker in canine intestinal adenocarcinoma, and further studies would be needed to develop EGFR-targeted anticancer therapies.

  6. www.nature.com › articles › s41598/023/37505-2Shared hotspot mutations in oncogenes position dogs as an ... -...

    6 lip 2023 · Canine tumors share mutational hotspots with human tumors in oncogenes including PIK3CA, KRAS, NRAS, BRAF, KIT and EGFR. Hotspot mutations with significant association to tumor type include...

  7. pubmed.ncbi.nlm.nih.gov › 31739412Current Approaches in NSCLC Targeting K-RAS and EGFR

    14 lis 2019 · Epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene homolog (K-RAS) are two of the main significant biomarkers for the management of NSCLC. Mutations in these genes were associated with development and response to therapies.

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