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  1. www.ncbi.nlm.nih.gov › pmc › articlesEGFR, HER-2 and KRAS in Canine Gastric Epithelial Tumors: A...

    15 sty 2014 · Epidermal growth factor receptor (EGFR or HER-1) and its analog c-erbB-2 (HER-2) are protein tyrosine kinases correlated with prognosis and response to therapy in a variety of human cancers. KRAS mediates the transduction of signals between EGFR and the nucleus, and its mutation has been identified as a predictor of resistance to anti-EGFR drugs.

  2. pubmed.ncbi.nlm.nih.gov › 24454858EGFR, HER-2 and KRAS in canine gastric epithelial tumors: a ... -...

    15 sty 2014 · Epidermal growth factor receptor (EGFR or HER-1) and its analog c-erbB-2 (HER-2) are protein tyrosine kinases correlated with prognosis and response to therapy in a variety of human cancers. KRAS mediates the transduction of signals between EGFR and the nucleus, and its mutation has been identified …

  3. journals.sagepub.com › doi › pdfEGFR Overexpression and Sequence Analysis of KRAS, BRAF, and EGFR...

    We evaluated EGFR expression at protein and mRNA levels in canine intestinal adenocarcinomas using immunohistochemistry (IHC) and RNA in situ hybridization (RNA-ISH). We also investigated the mutation status of EGFR, KRAS, and BRAF to aid the development of anti-EGFR agents for canine intestinal adenocarcinoma.

  4. www.nature.com › articles › s41698/023/00346-3Analyses of canine cancer mutations and treatment outcomes ... -...

    19 sty 2023 · The overlap of human and canine mutations associated with the therapeutic response using real-time data from pet dogs being treated for cancer can accelerate new drug development and help...

  5. pmc.ncbi.nlm.nih.gov › articles › PMC6036498Association between EGFR/KRAS mutation and expression of VEGFA,...

    The present study may help in the treatment of various patients with KRAS or subtype of EGFR mutation with anti-angiogenesis therapy. Keywords: lung adenocarcinoma, vascular endothelial growth factor A, vascular endothelial growth factor receptor, epidermal growth factor receptor mutation, Kirsten rat sarcoma viral oncogene homolog mutation ...

  6. pubmed.ncbi.nlm.nih.gov › 33926328EGFR Overexpression and Sequence Analysis of KRAS, BRAF, and EGFR...

    30 kwi 2021 · The EGFR, KRAS, and BRAF genes showed wild-type sequences at the mutation hot spots in all 13 specimens. Thus, EGFR might serve as a promising diagnostic marker in canine intestinal adenocarcinoma, and further studies would be needed to develop EGFR-targeted anticancer therapies.

  7. pubmed.ncbi.nlm.nih.gov › 18619559KRAS mutations predict response to EGFR inhibitors - PubMed

    Recent clinical data have provided substantial evidence that KRAS mutational status should be utilized as a diagnostic marker for predicting that response to anti-EGFR therapies in colorectal and non-small cell lung cancer.