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17 lip 2023 · Angiotensin II normally constricts the efferent arteriole, so ACE inhibitors (or angiotensin receptor blockers) dilate the afferent arteriole. Note that endogenously produced compounds (PGE2 and Angiotensin II) increase the GFR, and exogenous medications decrease the GFR (NSAIDS and ACEi or ARBs).
The efferent arterioles form a convergence of the capillaries of the glomerulus, and carry blood away from the glomerulus that has already been filtered. They play an important role in maintaining the glomerular filtration rate despite fluctuations in blood pressure.
2 lut 2021 · The GFR-lowering effect of tubuloglomerular feedback includes afferent arteriole constriction (via adenosine A1 receptor) and potentially efferent arteriole dilation (via adenosine A2 receptor), which both reduce glomerular capillary pressure (P GC).
13 sty 2023 · Afferent and efferent arterioles transport blood in and out of the glomerulus. Hypovolemia-induced reduction in glomerular filtration leads to decreased flow of NaCl to specialized epithelial cells (macula densa).
Vasodilation in the afferent arteriole and vasconstriction in the efferent arteriole will increase blood flow (and hydrostatic pressure) in the glomerulus and will increase GFR. Conversely, vasoconstriction in the afferent arteriole and vasodilation in the efferent arteriole will decrease GFR.
25 cze 2022 · Afferent arterioles bring blood into your kidney ’s glomerulus (blood vessels that filter your blood). Afferent arterioles can dilate, or get wider, to allow for more filtration. Efferent arterioles take blood out of your glomerulus. Arterioles in your lungs constrict or tighten when there’s not enough oxygen.
23 lut 2017 · Renin-angiotensin system blockers mediate efferent arteriolar vasodilatation and therefore an increase RBF while decreasing filtration fraction. Besides their impact on remodelling and prognosis in HF, RAAS-blockers lead to increased diuretic and natriuretic capacity in chronic (and acute HF), even in the face of a potential drop in GFR when ...
