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  1. Small amounts of nicotine can cause serious unwanted effects in children, and used gum or lozenges may contain enough nicotine to cause problems. If the gum or lozenges are swallowed, contact your doctor or poison control center at once.

  2. Should health care professionals avoid recommending NRT for patients with established cardiovascular disease? This article summarizes the mechanisms of harm associated with smoking and reviews the safety of NRT in both the general population and the population with cardiovascular disease.

  3. Nicotine replacement therapy is a proven effective pharma-cotherapy for smoking cessation. Anecdotal reports of ad-verse cardiac and vascular consequences resulting from the use of nicotine replacement products have led to cautious use or avoidance in the cardiovascular disease population.

  4. 1 wrz 1996 · This study shows that in healthy, middle-aged men, long-term exposure to smoke-free nicotine by the use of nicotine-containing chewing gum is associated with hyperinsulinemia and insulin resistance.

  5. Intravenous nicotine, nicotine nasal spray and nicotine chewing gum all acutely increase heart rate up to 10 to 15 beats/min and increase blood pressure up to 5 to 10 mm Hg, responses similar to the effects of cigarette smoking ([62–64]).

  6. 13 wrz 2010 · As reviewed in this statement, there is evidence that long-term ST product use may be associated with a modest risk of fatal myocardial infarction (MI) and fatal stroke, suggesting that ST product use may complicate or reduce the chance for survival after a MI or stroke.

  7. Nicotine may contribute to cardiovascular disease, presumably by hemodynamic consequences of sympathetic neural stimulation and systemic catecholamine release. However, there are many potential cardiovascular toxins in cigarette smoke other than nicotine.