Search results
5 lis 2021 · The diagnostic approach for beta-lactam (BL) drug hypersensitivity reactions (DHR) is based on the history, clinical signs, skin tests (ST), in vitro tests, and drug provocation tests (DPT). The aim of this study was to assess the performance of an allergy workup with ST in a real-world use.
Skin tests are useful for platinum salt-related immediate hypersensitivity reactions (moderate/strong) 50, while for other chemotherapeutic drugs, experience is limited and test results often negative (low/weak).
5 lut 2022 · Skin tests, including patch tests (PTs), prick tests, and intradermal tests (IDTs), are useful in identifying the culprits of cutaneous adverse drug reactions (CADRs), and determining safer, alternative drugs.
It is recommended that the physician administer a beta-lactam test dose with either penicillin or amoxicillin, based on patient circumstances, after a negative skin test, particularly when skin testing with a minor determinant mixture has not been performed.
Intradermal tests (IDTs) are performed by injecting 0.02 mL of the appropriately diluted suspected drug to evaluate immediate (with immediate readings) and delayed hypersen-sitivity reactions (with delayed readings). For IDTs, appropriate dilutions—summarized in this paper—have to be respected in order to avoid irritant false-positive reactions.
In immediate drug reactions, an IgE-mediated mechanism can be demonstrated by a positive skin prick and/or intradermal test after 20 minutes, whereas in non-immediate reactions, a T-cell involvement can be found by a positive patch test and/or a late-reading intradermal test.
10 lis 2023 · If skin test results are negative, proceed to DC, with flexible protocols depending on presentation and risk (ie, full vs subtherapeutic dose, and multiple-day courses if necessary). Cross-reactivity assessments are also considered here, if deemed necessary.
