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Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (C max) to half of C max in the blood plasma.
20 cze 2023 · The definition of elimination half-life is the length of time required for the concentration of a particular substance (typically a drug) to decrease to half of its starting dose in the body. Understanding the concept of half-life is useful for determining excretion rates as well as steady-state concentrations for any specific drug.
What is the half-life of a Drug? The half-life of a drug is an estimate of the time it takes for the concentration or amount in the body of that drug to be reduced by exactly one-half (50%). The symbol for half-life is t½. For example, if 100mg of a drug with a half-life of 60 minutes is taken, the following is estimated:
28 sie 2022 · In pharmacology, the time it takes for a drug to decrease by half its plasma (blood) concentration is called its half-life (t1⁄2). (Specifying that we're talking about biological half-life is key because the half-life is a concept not specific to medicine. For example, in nuclear physics, half-life refers to radioactive decay.)
HALF LIFE. Half-life refers to the rate at which 50% of a drug is eliminated from the body. Half-life can vary significantly between drugs. Some drugs have a short half-life of only a few hours and must be given multiple times a day, whereas other drugs have half-lives exceeding 12 hours and can be given as a single dose every 24 hours.
Definition. Biological half-life refers to the time required for the body to eliminate half of a substance, such as a radioactive isotope or a drug, through biological processes like metabolism and excretion.
A drug's half–life is the time required for a drug to reach 50% of steady-state levels during administration or to decay 50% from steady-state levels after administration ceases. From: Comprehensive Clinical Psychology , 1998
