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26 cze 2018 · Atomistic understanding of the metal–ligand interactions will help us identify potent metalloenzyme inhibitors and metallodrugs. Static docking calculations have proved effective in...
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7 gru 2021 · The design concepts regarding boron-containing MBPs are highlighted through the case analyses on five distinct classes of clinically relevant nucleophilic metalloenzymes from medicinal chemistry perspectives.
26 cze 2018 · The fast-growing body of experimental data on metalloenzymes and organometallic compounds is fostering the exploitation of metalligand interactions for the design of new drugs.
Atomistic understanding of the metal– ligand interactions will help us identify potent metalloenzyme inhibitors and metallodrugs. Static docking calculations have proved effective in...
26 sie 2019 · Metalloenzymes are attractive targets for therapeutic intervention owing to their central roles in various biological processes and pathological situations. The fast-growing body of structural data on metalloenzyme-ligand interactions is facilitating efficient drug discovery targeting metalloenzymes.
16 paź 2022 · These metalloenzyme classifications will guide different objectives in metalloenzyme research, e.g. metal-binding drug discovery and de novo design of metalloenzymes. Comprehensive information on metalloenzymes, including names, catalytic reaction, and family, is provided by MeDBA.
20 paź 2021 · This Review discusses the prospects and recent progress in utilizing ArMs in whole cells for applications in diverse areas such as drug therapy and integration with biosynthetic pathways.
