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Minocycline IR 200mg was associated with a tenfold greater reduction in P. acnes levels at Week 6 compared with doxycycline or tetracycline. After treatment discontinuation (Week 9), P. acnes levels remained lower in patients treated with minocycline IR than in those treated with either doxycycline or tetracycline.
17 sie 2023 · Doxycycline is one of the first-line treatments for acne and has replaced tetracycline in popularity. Oral doxycycline is started at a dose of 50 milligrams (mg) to 100 mg twice a day. It should be taken with food; otherwise, it can cause significant nausea.
11 lut 2021 · Chemical structures of the different tetracycline-class drugs use for the treatment of acne vulgaris. (A) Tetracycline. (B) Doxycycline. (C) Minocycline. (D) Sarecycline. The incorporation of a longer C7 moiety allows sarecycline to overcome tetracycline-resistant mechanisms mainly the efflux pump.
At the present time, doxycycline and minocycline are the most commonly prescribed tetracyclines in dermatology, used primarily for treatment of acne vulgaris with a long overall favorable track record of effectiveness and safety.
2 mar 2023 · A new Yale study examined sarecycline, a third-generation tetracycline derivative with a narrow-spectrum activity, which targets Cutibacterium acnes, the bacterium most doctors believe is behind acne and promotes skin inflammation.
2 mar 2017 · Tetracyclines, macrolides, and trimethoprim/sulfamethoxazole are effective and safe in the treatment of moderate to severe inflammatory acne. Superior efficacy of one type or class of antibiotic could not be determined, therefore the choice of antibiotic is generally based on the side-effect profile.
11 wrz 2020 · Established guidelines for acne treatment support treating moderate to severe acne and inflammatory acne that is resistant to topical treatments with systemic antibiotics. The guidelines recommend minocycline and doxycycline over tetracycline, outside of current market availability [39, 65].
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