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For example, amoxicillin could be administered to dogs at a dosage of 10 to 20 mg/kg q12h; however, to maintain higher drug concentrations, the same dose could be administered q8h. One method to ensure that the tissue or plasma drug concentration consistently exceeds the MIC is to deliver the antibiotic as a continuous IV infusion.
- JD Foster
Urinary Tract Infections in Dogs. Most UTIs are successfully...
- JD Foster
Although the labeled dose of amoxicillin for dogs and cats is sufficient, the labeled frequency (every 12 hours) may be less effective than dosing every 8 hours. More frequent dosing affects client compliance in administering the drug.
Selected antimicrobials: amoxicillin, amoxicillin clavulanate, cephalosporins, trimethoprim-sulfadiazine and enrofloxacin. Drugs should be given in 2 to 3 equal subdoses per day, and one of the dose administered prior to a period of confinement. The antimicrobial therapy should last for 10 days to 2 weeks.
27 cze 2011 · The interpretive criteria for susceptibility testing and breakpoints for systemic infections also apply to UTIs. Those drugs for which urinary tract-specific breakpoints have been provided are limited to ampicillin or amoxicillin in dogs (≤8 μg/mL), amoxicillin-clavulanate in dogs and cats <8/4 μg/mL), and nitrofurantoin. 2.1.2.
Treatment of intact male dogs requires antimicrobials that penetrate the prostate gland, e.g., fluoroquinolones, trimethoprim, doxycycline, and chloramphenicol. Penicillins and cephalosporins do not penetrate well and should not be used.
The minimum inhibitory concentration (MIC) susceptibility results are used to guide effective therapy by selection of an appropriate antibiotic and dosing range. Presumptive antibiotic treatment can be started while the results of a quantitative urine culture with MIC susceptibility testing are pending.
Elimination of the virulent organism can enable restoration of the normal permeability and integrity of the urothelium. Successful antimicrobial therapy requires an appropriate choice of antibiotic, including dose, frequency, and duration. UTI Diagnosis and Localization. The gold standard for UTI diagnosis is urine culture.
