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For example, amoxicillin could be administered to dogs at a dosage of 10 to 20 mg/kg q12h; however, to maintain higher drug concentrations, the same dose could be administered q8h. One method to ensure that the tissue or plasma drug concentration consistently exceeds the MIC is to deliver the antibiotic as a continuous IV infusion.
- JD Foster
Urinary Tract Infections in Dogs. Most UTIs are successfully...
- JD Foster
In dogs and cats, amoxicillin is more bioavailable (better absorbed from the GI tract) than is ampicillin, so its dosage is lower. Absorption of ampicillin is also affected by feeding, so successful treatment may be easier to achieve with amoxicillin.
Selected antimicrobials: amoxicillin, amoxicillin clavulanate, cephalosporins, trimethoprim-sulfadiazine and enrofloxacin. Drugs should be given in 2 to 3 equal subdoses per day, and one of the dose administered prior to a period of confinement. The antimicrobial therapy should last for 10 days to 2 weeks.
Successful antimicrobial therapy requires an appropriate choice of antibiotic, including dose, frequency, and duration. UTI Diagnosis and Localization. The gold standard for UTI diagnosis is urine culture.
Treatment of intact male dogs requires antimicrobials that penetrate the prostate gland, e.g., fluoroquinolones, trimethoprim, doxycycline, and chloramphenicol. Penicillins and cephalosporins do not penetrate well and should not be used.
Trimethoprim-sulfonamide is another first tier option but may be associated with greater adverse event concerns and is difficult to recommend over amoxicillin or amoxicillin/clavulanic acid. The recommended duration of therapy is 3–5 days. The short end of that dosing period may be optimal, but veterinary research is currently limited.
1 maj 2019 · This document is a revision and expansion on the 2011 Antimicrobial Use Guidelines for Treatment of Urinary Tract Disease in Dogs and Cats, providing recommendations for diagnosis and management of sporadic bacterial cystitis, recurrent bacterial cystitis, pyelonephritis, bacterial prostatitis, and subclinical bacteriuria.
