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Lymphoma (malignant lymphoma or lymphosarcoma) in dogs arises from the uncontrolled and pathological clonal expansion of lymphoid cells of either B-cell or T-cell immunophenotype. Usually primary and secondary lymphoid tissues are involved, including the bone marrow, thymus, lymph nodes, and spleen.
Lymphoma is a neoplasm arising from the malignant transformation of lymphocytes. Generally, this is a disease of middle-aged to older dogs, although many young dogs can develop the condition. Figure 1. Lymphoma cytology. Lymph node fine-needle aspirate of a dog with typically high-grade/large cell lymphoma.
The minimum amount of diagnostic evaluation acceptable before treating a patient with LSA is a diagnosis via FNA, CBC, chemistry profile and urinalysis. Thorough staging of animals with lymphoma includes: Complete blood count: May be normal, or may reveal anemia, cytopenias or a lymphoid leukemia.
Malignant lymphoma is a common cancer in dogs. It is a progressive, deadly disease caused by the harmful growth of lymphocytes. Lymphoma most commonly arises from lymphoid tissues in the bone marrow, thymus, lymph nodes, or spleen. Other common sites include the skin, eye, central nervous system, and bone. Although it is common, the causes and ...
A complete blood count (CBC) can indicate if there is likely bone marrow involvement (cytopenias, lymphoblasts in circulation) or an immune-mediated thrombocytopenia. A full chemistry panel can reveal elevations in liver enzymes or renal values, which could be supportive of other organ involvement.
For most dogs with multicentric lymphoma, diagnostic evaluation should include a complete blood count (CBC), serum chemistry panel, urinalysis, thoracic radiographs, and abdominal ultrasound. Thoracic radiographic changes consistent with lymphoma may include diffuse or localized pulmonary
Given how common lymphoma is in dogs, it’s important for all dog owners to understand the common signs of lymphoma as well as the basics of diagnosis and treatment in order to make the best and most informed decisions for your dog.
