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The minimum amount of diagnostic evaluation acceptable before treating a patient with LSA is a diagnosis via FNA, CBC, chemistry profile and urinalysis. Thorough staging of animals with lymphoma includes: Complete blood count: May be normal, or may reveal anemia, cytopenias or a lymphoid leukemia.
A complete blood count (CBC) can indicate if there is likely bone marrow involvement (cytopenias, lymphoblasts in circulation) or an immune-mediated thrombocytopenia. A full chemistry panel can reveal elevations in liver enzymes or renal values, which could be supportive of other organ involvement.
Lymphoma (malignant lymphoma or lymphosarcoma) in dogs arises from the uncontrolled and pathological clonal expansion of lymphoid cells of either B-cell or T-cell immunophenotype. Usually primary and secondary lymphoid tissues are involved, including the bone marrow, thymus, lymph nodes, and spleen.
Lymphoma is a neoplasm arising from the malignant transformation of lymphocytes. Generally, this is a disease of middle-aged to older dogs, although many young dogs can develop the condition. Figure 1. Lymphoma cytology. Lymph node fine-needle aspirate of a dog with typically high-grade/large cell lymphoma.
Firstly, to discover suitable and measurable biomarker tests for canine lymphoma. Secondly, to refine a testing system using mathematical models capable of quantifying and monitoring disease progress in dogs diagnosed with lymphoma. Two biomarkers were discovered using mass spectrometry.
For most dogs with multicentric lymphoma, diagnostic evaluation should include a complete blood count (CBC), serum chemistry panel, urinalysis, thoracic radiographs, and abdominal ultrasound. Thoracic radiographic changes consistent with lymphoma may include diffuse or localized pulmonary
Canine lymphoma is often relatively easy to diagnose by taking a small sample of tissue or cells from the affected organ system. In dogs with multicentric lymphoma, a needle biopsy of enlarged lymph nodes usually provides enough cells to confirm the diagnosis.
