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22 lut 2023 · The present systematic review and meta-analysis showed lower systemic concentrations of thiamine, TMP, and total thiamine in individuals with diabetes compared to those without diabetes, while TDP and erythrocyte transketolase activity tended to be lower in the diabetes group without reaching statistical significance.
12 maj 2011 · This review examines the mechanisms by which thiamine deficiency occurs in individuals with diabetes, how this deficiency leads to hyperglycaemic-induced damage, and the effect of thiamine replacement on vascular disease, endothelial function and oxidative stress.
8 maj 2020 · Diabetes has been found to be associated with low levels of thiamine stores in the body, as thiamine directly affects carbohydrate metabolism. Amplified renal clearance of thiamine has been found in both type I and type II diabetic patients.
The first evidence of the beneficial effects of thiamine on microvascular cells involved in diabetic complications dates to 1996: from then on, several papers based on in vitro and animal models have addressed the potential use of this vitamin in counteracting diabetic microangiopathy.
31 gru 2019 · Interpretation: Thiamine supplementation does not affect glycaemic outcomes, however reduces triglycerides while increasing HDL. Multicentre well-designed RCT with higher doses of thiamine and a follow-up period of 1–2 years will provide better evidence.
5 cze 2021 · “In clinical trials of vitamin B1 (thiamin) in cases of diabetes the author, during the past few years, has found that administration of thiamin, either parenterally or orally, effects some improvement in the carbohydrate tolerance of the diabetic patient and has further observed an apparent economy of insulin in several instances after its ...
One-month thiamine admin-istration decreased glycemia and leptin concentrations in subjects with type 2 diabetes [37], and improvements were described in glucose tolerance [38] and blood pressure [39] in subjects with hyperglycaemia, following high-dose thia-mine supplementation.
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