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8 maj 2020 · Diabetes has been found to be associated with low levels of thiamine stores in the body, as thiamine directly affects carbohydrate metabolism. Amplified renal clearance of thiamine has been found in both type I and type II diabetic patients.
- The Impact of Thiamine Treatment in the Diabetes Mellitus
The relationship between thiamine and diabetes mellitus was...
- Thiamine and diabetes: back to the future? - PubMed
The first evidence of the beneficial effects of thiamine on...
- The Impact of Thiamine Treatment in the Diabetes Mellitus
15 maj 2012 · The relationship between thiamine and diabetes mellitus was discussed. Thiamine definitively has a role in the diabetic endothelial vascular diseases (micro and macroangiopathy), lipid profile, retinopathy, nephropathy, cardiopathy, and neuropathy.
22 lut 2023 · The present systematic review and meta-analysis showed lower systemic concentrations of thiamine, TMP, and total thiamine in individuals with diabetes compared to those without diabetes, while TDP and erythrocyte transketolase activity tended to be lower in the diabetes group without reaching statistical significance.
12 maj 2011 · This review examines the mechanisms by which thiamine deficiency occurs in individuals with diabetes, how this deficiency leads to hyperglycaemic-induced damage, and the effect of thiamine replacement on vascular disease, endothelial function and oxidative stress.
5 cze 2021 · The first reports of a link between thiamine and diabetes date back to the 1940s. Some years later, a role for thiamine deficiency in diabetic neuropathy became evident, and some pilot studies evaluated the putative effects of thiamine supplementation.
The first evidence of the beneficial effects of thiamine on microvascular cells involved in diabetic complications dates to 1996: from then on, several papers based on in vitro and animal models have addressed the potential use of this vitamin in counteracting diabetic microangiopathy.
Thiamine levels and thiamine-dependent enzyme activities have been reduced in DM. Genetic studies provide opportunity to link the relationship between thiamine and DM (such as Tk, SLC19A2 gene, transcription factor Sp1, α-1-antitrypsin, and p53).
