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DNA polymerase III holoenzyme is the primary enzyme complex involved in prokaryotic DNA replication. It was discovered by Thomas Kornberg (son of Arthur Kornberg) and Malcolm Gefter in 1970.
Classical models define DNA Pol-III holoenzyme as a multiprotein complex that contains two Pol-III core polymerases, two β sliding clamps, and a single γ complex clamp loader (reviewed in [18,19]).
The  subunits dimerize to form the sliding clamp that links the core polymerase to DNA and allows DNA replication to proceed; four  subunits are present in the DNA polymerase III...
DNA polymerase III holoenzyme (Pol III HE) is an enzyme that catalyzes elongation of DNA chains during bacterial chromosomal DNA replication. Bacterial cells contain several distinct DNA polymerases.
29 cze 2001 · The DNA polymerase III holoenzyme is composed of ten distinct proteins (Onrust et al., 1995) that are organized into three functional modules: (1) Pol III, which contains the holoenzyme's polymerase (α subunit) and exonuclease (ϵ subunit) activities; (2) the toroidal-shaped processivity “clamp” β, which tethers Pol III to DNA; and (3 ...
12 sty 1996 · For simplicity, the diagram shows only pol III core and the γ complex. Other components of the pol III holoenzyme, including the τ subunit and the second pol III core molecule that mediates leading strand synthesis, are omitted. The timing of ATP hydrolysis is speculative.
1 sty 1981 · DNA polymerase III holoenzyme is a complex, multisubunit enzyme responsible for most of the replicative synthesis in E. coli. It contains a core (pol III) that can repair short gaps created by nuclease in duplex DNA. Pol III contains three subunits—namely, (1) α (dnaE protein), (2) є, and (3) θ.
