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14 lis 2024 · A DNA model that unifies information across the molecular, systems, and genome scales could learn from large genomic regions to capture systems-wide interactions and enable the design of more-sophisticated biological functions.
5 paź 2022 · We present here the pyDockDNA web server, which can successfully model a protein-DNA complex with a reasonable predictive success rate (as benchmarked on a standard dataset of protein-DNA complex structures, where DNA is in B-DNA conformation).
12 cze 2023 · GENA-LM is a transformer-based architecture, pre-trained using a masked language modeling (MLM) objective on DNA sequences. The input sequence is divided into tokens using the BPE algorithm and then fed into the transformer layers.
13 cze 2023 · To address this need, we introduce GENA-LM, a suite of transformer-based foundational DNA language models capable of handling input lengths up to 36 thousands base pairs.
21 lip 2020 · A data model supporting different DNA nanostructure concepts (multilayer DNA origami, wireframe DNA origami, DNA tiles etc.) has been developed allowing the creation of new and the import of existing DNA nanostructures.
9 lis 2021 · In this 2022 update, we have uniformly processed >11 000 DNA-binding sequencing datasets from public sources across four species. The updated Human regulatory atlas includes 8103 datasets covering a total of 1210 transcriptional regulators (TRs) with a catalog of 182 million (M) peaks, while the updated Arabidopsis atlas reaches 4.8M peaks, 423 ...
12 wrz 2022 · Mathematically modelling the complex network of genes and processes that make up the DNA repair network will not only provide insight into how cells recognise and react to mutations, but it may also reveal whether or not genes involved in the repair process can be controlled.
