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24 lip 2018 · 3,5-T2 (1.25 mg/100 g BW via daily gavage) reduces circulating total and LDL cholesterol as well as the liver level of apoB and circulating levels of both apoB48 and apoB100, but, at the same time, reduces plasma T4 levels in Western type diet fed low-density lipoprotein receptor knockout mice . Both 3,5-T2 and T3 administration significantly ...
25 lip 2018 · Here, we provide an overview of the most recent literature on 3,5-T2 bioactivity with a particular focus on short-term and long-term effects, describing data obtained through in vivo and in vitro approaches in both mammalian and non-mammalian species.
15 gru 2017 · An overview of direct and rapid effects of 3,5-diiodothyronine is proposed. • The mechanism relies on regulation of mitochondrial activities. • 3,5-Diiodothyronine plays a role in thyroid endocrinology.
1 kwi 2014 · The administration of 3,5-T2 suppressed thyroid function, reducing not only thyroid iodide uptake but also thyroperoxidase, NADPH oxidase 4 (NOX4) and thyroid type 1 iodothyronine...
7 sty 2020 · 3,5-T2, in contrast to its structural isomers 3,3′-T2 and 3′,5′-T2, is an active ligand for the classical T3 receptors (TR), where it binds with relative high affinity and modulates transcriptional activity of TR, as indicated e.g., by rapid and powerful suppression of TSH in vivo, altered 3,5-T2 modulated gene expression in vitro and in ...
Jonas W, Lietzow J, Wohlgemuth F, et al. 3,5-diiodo-L-thyronine (3,5-T2) exerts thyromimetic effects on hypothalamus-pituitary-thyroid axis, body composition, and energy metabolism in male diet-induced obese mice.
1 sty 2015 · Herein, we aim to understand the role of 3,5-T2 in regulating central and peripheral inflammation in D.I.O. model of zebrafish. 3,5-T2 (10 nM and 100 nM) was administered with the...
