Search results
1 lut 2024 · Digoxin is used to treat congestive heart failure, usually in combination with a diuretic (water pill) and an angiotensin-converting enzyme (ACE) inhibitor. It is also used to treat a heart rhythm problem called atrial fibrillation.
8 sie 2024 · Digoxin toxicity is a clinical diagnosis that relies in part on ECG findings such as signs of increased automaticity and atrioventricular node blockade (premature ventricular contractions, slowed ventricular response), but also on clinical features, history of digoxin intake, history of other illnesses, and elevated digoxin concentrations.
The diagnosis of digoxin toxicity is based primarily on clinical suspicion and clinical features (including ECG changes) suggestive of digoxin intoxication, and can be confirmed by assessment of serum digoxin levels.
Digoxin has a relatively narrow therapeutic window. For heart failure alone, the target serum levels should be between 0.5 and 1.0 ng/L. For AF, the target range is higher (0.5-2.0 ng/L).16It is primarily excreted by the kid-neys and should be used carefully in patients with chronic kidney disease.
Digoxin effects on cardiac function and ECG. Digoxin has a positive inotropic effect and a negative chronotropic effect, enhancing ventricular contractility while lowering heart rate. The positive inotropic effect is due to the inhibition of the sodium-potassium adenosine triphosphatase (NaK-ATPase) in the ventricular myocardium.
21 sie 2023 · INTRODUCTION. Cardiac glycosides have important positive inotropic, neurohormonal, and electrophysiologic actions, which are the basis for its use in two clinical situations: heart failure due to systolic dysfunction, and in certain supraventricular tachyarrhythmias. The ability of digoxin to reduce sympathetic activation has also been recognized.
10 cze 2021 · Digoxin toxic effects may be manifested as nonspecific gastrointestinal symptoms, visual disturbance, and characteristic electrocardiographic changes (such as atrial tachycardia, AV block, junctional rhythms, regularized AF).
