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13 cze 2005 · The mechanism of action of diethylcarbamazine is thought to involve sensitizing the microfilariae to phagocytosis. One study showed that diethylcarbamazine's activity against Brugia malayi microfilariae is dependent on inducible nitric-oxide synthase and the cyclooxygenase pathway.
Diethylcarbamazine is a medication used in the treatment of filariasis including lymphatic filariasis, tropical pulmonary eosinophilia, and loiasis. [1] It may also be used for prevention of loiasis in those at high risk. [1]
28 lip 2020 · Verma et al. describe a new mechanism for diethylcarbamazine action, a drug classically used to treat lymphatic filariasis and loiasis.
9 gru 2022 · Diethylcarbamazine (DEC) is used to treat lymphatic filariasis and activates TRP-2, GON-2 & CED-11 TRP channels in Brugia malayi muscle cells producing spastic paralysis.
The mechanism of action of diethylcarbamazine involves two processes: • first, filarial muscular activity decreases, probably secondary to hyperpolarization of membranes by the piperazine moiety of diethylcarbamazine; and • second, microfilarial surface membranes are altered by making them more susceptible to host defenses.
5 lip 2014 · Diethylcarbamazine (DEC) has been used successfully by public health authorities as a key tool in the elimination of lymphatic filariasis in several countries. Its filaricidal activity was discovered in a study by Hewitt et al. (1947) of wild cotton rats infected with Litomosoides sigmodontis.
20 mar 2020 · Improvement was better with diethylcarbamazine compared to montelukast and levocetirizine and the effects were sustained for 3 months in diethylcarbamazine group. The findings suggest that diethylcarbamazine is effective in the treatment of allergic rhinitis.
