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13 cze 2005 · Mechanism of action. The mechanism of action of diethylcarbamazine is thought to involve sensitizing the microfilariae to phagocytosis. One study showed that diethylcarbamazine's activity against Brugia malayi microfilariae is dependent on inducible nitric-oxide synthase and the cyclooxygenase pathway.
Dietylokarbamazyna (łac. diethylcarbamazinum) – wielofunkcyjny organiczny związek chemiczny, pochodna piperazyny, stosowana jako ogólnoustrojowy lek przeciwrobaczy. Mechanizm działania dietylokarbamazyny nie jest znany, wiadomo jednak, że wpływa na szlak kwasu arachidonowego [5]. Zastosowanie.
Diethylcarbamazine is a medication used in the treatment of filariasis including lymphatic filariasis, tropical pulmonary eosinophilia, and loiasis. [1] It may also be used for prevention of loiasis in those at high risk. [1]
20 mar 2020 · This study evaluated the effectiveness of diethylcarbamazine in the treatment of allergic rhinitis and compared it with montelukast and levocetirizine. This parallel double-blind randomized clinical trial was done in allergic rhinitis patients.
28 lip 2020 · Verma et al. describe a new mechanism for diethylcarbamazine action, a drug classically used to treat lymphatic filariasis and loiasis.
9 gru 2022 · Diethylcarbamazine (DEC) is used to treat lymphatic filariasis and activates TRP-2, GON-2 & CED-11 TRP channels in Brugia malayi muscle cells producing spastic paralysis. DEC also has stimulatory...
The mechanism of action of diethylcarbamazine involves two processes: •. first, filarial muscular activity decreases, probably secondary to hyperpolarization of membranes by the piperazine moiety of diethylcarbamazine; and. •. second, microfilarial surface membranes are altered by making them more susceptible to host defenses.
