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Two families of α-adrenergic receptors exist. Radiolabeled agonists and antagonists have been used to label α receptors in both the brain and the peripheral tissues. As with β receptors, the binding properties of α receptors are essentially the same in the brain and the periphery.
10 lip 2023 · Objectives: Identify the two predominant types of alpha-adrenergic receptors. Describe the effects of agonistic and antagonistic activity on the various alpha receptors. Summarize the potential adverse effects for each type of alpha agonist or antagonist medication class.
Alpha adrenergic receptors are defined as receptors that mediate the biological actions of catecholamines, such as norepinephrine and epinephrine. They are further classified into α1 and α2 subtypes, with α1 receptors causing constriction and α2 receptors modulating norepinephrine release.
Distribution, density, and activity of receptors in the brain can be visualized by radioligands labeled for SPECT and PET, and the receptor binding can be quantified by appropriate tracer kinetic models, which can be modified and simplified for particular application.
receptors. Alpha-adrenergic receptors are mem- brane glycoproteins with several common struc- tural features (including seven membrane-span- ning domains with extracellular amino terminus and intracellular carboxyl terminus) that are shared with other tvoes of membrane receotors
Well-known examples include the β-adrenergic receptor, the muscarininc type of acetylcholine receptor, metabotropic glutamate receptors, receptors for odorants in the olfactory system, and many types of receptors for peptide hormones.
Alpha1 and alpha2-adrenergic receptors are the initial recognition sites on a wide variety of catecholamine-responsive target cells. This article addresses several major questions related to subtypes, structure, signal transduction mechanisms, and regulation of alpha1 and alpha2-adrenergic receptors.
