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The EPA recommends that the toxicity equivalence factor (TEF) methodology, a component mixture method, be used to evaluate human health risks posed by these mixtures, using TCDD as the index chemical. The EPA recommends the use of the consensus TEF values for TCDD and the DLCs published in 2005 by the World Health Organization.
This paper provides a critical view of the advances made towards understanding the mechanism of TCDD action. Major topics discussed include the Ah-receptor hypothesis, TCDD as a thyroid hormone agonist, TCDD and vitamin A deficiency, TCDD's effect on receptor regulation, and its effect on intermediary metabolism including related hormonal ...
30 paź 2021 · 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a polyhalogenated planar hydrocarbon belonging to a group of highly toxic and persistent environmental contaminants known as “dioxins”. TCDD is an animal teratogen and carcinogen that is well characterized for causing immunosuppression through activation of aryl hydrocarbon receptor (AHR).
Of the 75 possible isomers of polychlorinated dibenzodioxin, the specific isomer designated 2,3,7,8-tetrachlorodibenzodioxin (TCDD; dioxin) is most toxic and generally is considered the most toxic synthetic molecule known.
The “Toxic Equivalent” (TEQ) scheme weighs the toxicity of the less toxic compounds as fractions of the toxicity of the most toxic TCDD. Each compound is attributed a specific “Toxic Equivalency Factor” (TEF) .
2,3,7,8-Tetrachlorodibenzodioksyna, TCDD – organiczny związek chemiczny z grupy dioksyn o bardzo dużej toksyczności. Związek ten został prawdopodobnie wykorzystany do usiłowania otrucia Wiktora Juszczenki jesienią 2004 roku w czasie kampanii prezydenckiej na Ukrainie.
21 cze 2015 · Abstract. Dioxins are widespread persistent environmental contaminants with adverse impacts on humans and experimental animals. Behavioral and cognitive functions are impaired by...
