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Patients with resistant skin lesions require additional immunosuppressive therapy with weekly methotrexate (dose, 10-25 mg), azathioprine (1-2.5 mg/kg per day), or MMF (2-3 g/d). 38 Dapsone therapy (25-150 mg) is useful for patients with urticarial vasculitis, oral ulcerations, and bullous rash of SLE. Dapsone therapy can result in hemolysis ...
21 paź 2022 · Complementary and alternative treatments for lupus include: Dehydroepiandrosterone (DHEA). Taking supplements containing this hormone along with conventional treatment may help reduce lupus flares. dehydroepiandrosterone (DHEA) may lead to acne in women. Fish oil.
Dapsone is a highly effective treatment for BSLE; in severe or recalcitrant cases, steroids or immunosup-pressants are viable alternatives.4. POTENTIAL COMPETING INTERESTS. The authors report no potential competing interests. ACKNOWLEDGMENTS. The authors thank Laura Ragmanauskaite, MD, for her care of the patient and photography.
Dapsone is occasionally used in the treatment of the autoimmune bullous diseases, a group of disorders resulting from autoimmunity directed against basement membrane and/or intercellular adhesion molecules on cutaneous and mucosal surfaces. This review will summarize the limited published data evaluating dapsone as a therapy for the AIBD.
Furthermore, dapsone has been tested to treat bullous systemic lupus erythematosus, a rare bullous condition associated with systemic lupus erythematosus . The results showed that dapsone was effective in 90% of the cases to diminished dermal infiltration of polynuclear neutrophils, alignment of these cells at the basal membrane zone and ...
22 maj 2023 · Bullous systemic lupus erythematosus (BSLE) is a rare manifestation of systemic lupus erythematosus. It has clinical and histological features that may lead to misdiagnosis and delayed treatment of this easily treatable condition.
Oral dapsone is sometimes used for rheumatologic skin diseases. It is most commonly used to treat some forms of cutaneous lupus erythematosus (including bullous lupus), vasculitis, and conditions due to increased neutrophils (neutrophilic dermatoses).
