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Despite an increasing knowledge of dandruff and seborrheic dermatitis (D/SD), the pathophysiological understanding is still incomplete but suggests a role of Malassezia yeasts in triggering inflammatory and hyper-proliferative epidermal responses.
The word dandruff (dandruff, dandriffe) is of Anglo-Saxon origin, a combination of ‘tan’ meaning ‘tetter’ and ‘drof’ meaning ‘dirty’. Dandruff affects aesthetic value and often causes itching.
Dandruff (pityriasis capitis, seborrheic dermatitis confined to the scalp) is a disease that has been around for centuries despite several treatment options. [1] Dandruff should not be defined only by its clinical presentation, pathophysiology and/or its etiological spectrum.
5 sty 2021 · Dandruff is a disease of the scalp in which fungi belonging to the genus Malassezia are thought to play an important role. These fungi are also invariably present on the scalp of dandruff-free individuals. The disease results in flaking of the scalp and affects about 50% of adults worldwide.
18 gru 2019 · Our results show that characteristic bacterial and fungal communities are associated with dandruff and non-dandruff scalps, while adding quantitative assessment of targeted Staphylococcus species not previously described.
11 kwi 2019 · Dandruff is considered a mild type of seborrheic dermatitis limited to the scalp. The ethiopathogenesis of the disease is not fully understood and, for years, has been associated with an inflammatory response to yeasts.
The role of Malassezia in dandruff and seborrheic dermatitis is supported by the efficacy of a variety of antifungal agents (i.e., pyrithione zinc, selenium sulfide, ciclopirox olamine, climbazole, and ketoconazole) with no other obvious related biological activity.
