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19 kwi 2023 · They delivered it to the inner ear of a normal adult mouse with damaged hair cells — an important distinction, as wild-type, non-transgenic mice would be more translatable to humans. They further delivered the gene Atoh1 by a gene therapy approach that utilizes a harmless adenovirus into the cocktail-treated inner ear.
Sensory hair cells of the inner ear are exposed to continuous mechanical stress, causing damage over time. The maintenance of hair cells is further challenged by damage from a variety of other ototoxic factors, including loud noise, aging, genetic defects, and ototoxic drugs.
17 godz. temu · This review summarised the literature concerning the important roles played by SCs following the occurrence of inner ear damage, including initial structural repair and the reprogramming process for HC regeneration, and discussed approaches to enhance this process. ... Math1: an essential gene for the generation of inner ear hair cells. Science ...
7 lip 2023 · Prolonged exposure to loud noise harms hair cells in a variety of ways, and one of those is by damaging the cores of the “hairs” themselves. These hair-like structures are known as stereocilia, and Shin’s new research shows a process they use to repair themselves.
24 maj 2022 · Hair-cell damage is repaired in the ears of regenerative species through two processes: transdifferentiation and asymmetric division. Transdifferentiation occurs when supporting cells directly differentiate into hair cells without first undergoing division.
13 kwi 2019 · Sensory hair cells of the inner ear are exposed to continuous mechanical stress, causing damage over time. The maintenance of hair cells is further challenged by damage from a variety of other ototoxic factors, including loud noise, aging, genetic defects, and ototoxic drugs.
10 lip 2023 · FULL STORY. University of Virginia School of Medicine researchers have discovered how the cells that let us hear can repair themselves after being damaged. That important insight could benefit...
