Search results
The evidence that the risk of cancer is increased among users of artificial sweeteners is inconsistent 1. Since the positive report of Howe et al. 2, reports have become available on six case-control studies and on one population study of bladder cancer.
1 sty 2000 · Based on subsequent toxicity and carcinogenicity studies, a report was published by a review panel at the National Cancer Institute concluding that it could not be established that cyclamate was not carcinogenic in experimental animals (DHEW publication, 1976).
No previous study has described the effects of chronic consumption of the cyclamate and saccharin combination on oxidative stress, lipid profile, glycemic control, creatinine, and alanine transaminase activity in healthy individuals and in patients with type 2 diabetes mellitus (T2DM).
No national or international occupational exposure limits have been proposed for cyclamic acid, sodium cyclamate, or calcium cyclamate in workplace air, and no international guidelines for cyclamates in drinking-water have been established .
The Scientific Committee for Food (SCF) reviewed the toxicity of cyclamate, cyclohexylamine and dicyclohexylamine in 1985 and established a temporary ADI of 0-11 mg/kg bodyweight (bw), expressed as cyclamic acid, for cyclamic acid and its sodium and calcium salts (1).
Cyclamate (E952) is generally used in the form of a sodium salt because it is more soluble in water than the free acid. The calcium salt is also used as a sweetener, but, for some applications, it is not suitable as it can cause gelation and precipitation.
28 sie 2024 · A 2023 review concluded that artificial sweeteners are associated with hypertension, insulin resistance, high blood sugar, abdominal obesity, and dyslipidemia .
