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Chromosomal aberrations were not induced in the spermatogonia of mice or Chinese hamsters exposed to sodium cyclamate in drinking-water for 150 days or by gavage for five consecutive days, respectively.
The Scientific Committee for Food (SCF) reviewed the toxicity of cyclamate, cyclohexylamine and dicyclohexylamine in 1985 and established a temporary ADI of 0-11 mg/kg bodyweight (bw), expressed as cyclamic acid, for cyclamic acid and its sodium and calcium salts (1).
Sodium cyclamate is a potent sweetening agent. It has been subjected to numerous safety and carcinogenicity studies. Animal data led to warning against excessive and indiscriminate use a long time ago, causing the World Health Organization in 1967 to adopt a safety limit of 50 mg/kg.
Cyclamate [IV] is generally used in the form of a sodium salt [V] because it is more soluble in water than the free acid. The calcium salt is also used as a sweetener, but, for some applications, it is not suitable as it can cause gelation and precipitation.
9 kwi 2022 · For sodium cyclamate and CHA, the critical effects identified for characterizing the risk to human health are potential effects on the testes. According to information considered under the ERC Approach, sodium cyclamate and CHA were identified as having low ecological hazard potential.
1 sty 2000 · The present study evaluated the long-term toxic and carcinogenic effects of sodium cyclamate on three monkey species. Of the 21 monkeys that were started on cyclamate as newborns in 1970, 14 survived until the study was terminated in 1994.
Cyclamate acts as an allosteric agonist at the T1R3 subunit of T1R2/T1R3, and notably, exclusively at the human T1R3 (Jiang et al., 2005b). By contrast, cyclamate acts as an allosteric enhancer at the T1R3 subunit of T1R1/T1R3, thus requiring the presence of an orthosteric agonist such as Glu (Xu et al., 2004).
