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Cyclamate (E952) is generally used in the form of a sodium salt because it is more soluble in water than the free acid. The calcium salt is also used as a sweetener, but, for some applications, it is not suitable as it can cause gelation and precipitation.
Chromosomal aberrations were not induced in the spermatogonia of mice or Chinese hamsters exposed to sodium cyclamate in drinking-water for 150 days or by gavage for five consecutive days, respectively.
Cyclamate is an artificial sweetener. It is 30–50 times sweeter than sucrose (table sugar), making it the least potent of the commercially used artificial sweeteners. It is often used with other artificial sweeteners, especially saccharin ; the mixture of 10 parts cyclamate to 1 part saccharin is common and masks the off-tastes of both ...
ACUTE/CHRONIC HAZARDS: This compound is harmful by ingestion, inhalation and skin absorption. It may cause irritation of the skin, eyes, mucous membranes and upper respiratory tract. When heated to decomposition it emits very toxic fumes of sodium oxide, carbon monoxide, carbon dioxide, nitrogen oxides and sulfur oxides. (NTP, 1992)
cyclamate, odourless white crystalline powder that is used as a nonnutritive sweetener. The name usually denotes either calcium cyclamate or sodium cyclamate, both of which are salts of cyclohexylsulfamic acid (C 6 H 1 1 NHSO 3 H). These compounds are stable to heat and are readily soluble in water.
1 sty 2000 · The present study evaluated the long-term toxic and carcinogenic effects of sodium cyclamate on three monkey species. Of the 21 monkeys that were started on cyclamate as newborns in 1970, 14 survived until the study was terminated in 1994.
The Scientific Committee for Food (SCF) reviewed the toxicity of cyclamate, cyclohexylamine and dicyclohexylamine in 1985 and established a temporary ADI of 0-11 mg/kg bodyweight (bw), expressed as cyclamic acid, for cyclamic acid and its sodium and calcium salts (1).
