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Sodium cyclamate was tested for carcinogenicity both alone and in combination with other chemicals in different animal species and by several routes of administration.
Regulators weigh in favorably about cyclamate. Use is approved in more than 100 countries, including Europe, Mexico, Australia. The conclusion that cyclamate can be safely consumed has been reached by an increasing number of governments throughout the world.
1 sty 2000 · The present study evaluated the long-term toxic and carcinogenic effects of sodium cyclamate on three monkey species. Of the 21 monkeys that were started on cyclamate as newborns in 1970, 14 survived until the study was terminated in 1994.
Sodium cyclamate is a potent sweetening agent. It has been subjected to numerous safety and carcinogenicity studies. Animal data led to warning against excessive and indiscriminate use a long time ago, causing the World Health Organization in 1967 to adopt a safety limit of 50 mg/kg.
Cyclamates are produced from cyclohexylamine (obtained by the reduction of aniline) by sulfonation (Bizzari et al., 1996). Production of sodium and calcium cyclamates in western Europe (annual capacity, 4200 tonnes) in 1995 was estimated to be 4000 tonnes.
29 paź 2019 · The cyclamate bandwagon has made farcical progress in the past week … The truth is that cyclamates have been banned because they are easy to ban, and the new evidence provides the slenderest...
This review of the published and unpublished literature on cyclamate attempts to evaluate the carcinogenicity question and other important aspects of the toxicity of cyclamate and cyclohexylamine, including their effects on various organ systems, their genotoxic potential, and their effects on reproduction.
