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Radioactive cyclamate was administered intravenously to women undergoing therapeutic abortion by abdominal hysterectomy in early pregnancy. Distribution in fetal tissues was studied by direct counting and autoradiography. Cyclamate crossed
Cyclamate is currently banned for use in the U.S., and there is insufficient data regarding the safety of its use during pregnancy. If you use artificial sweeteners and are pregnant, it is always best to talk with your health care provider regarding which sweetener you use and how much you consume.
Which artificial sweeteners are safe during pregnancy? Six sweeteners: aspartame (NutraSweet and Equal), sucralose (Splenda), saccharin (Sweet'N Low), acesulfame potassium, neotame, and advantame have all been approved as safe by the FDA. In general, all of these, except for saccharin, are considered safe to use in moderation during pregnancy.
In Canada, the odds ratio for use of cyclamate was 1.09 (0.60–1.97) in males and 0.92 (0.63–1.36) in females 16. In neither study were the increased risks seen in subgroups in other studies replicated.
In pregnant rats, significant amounts of sodium cyclamate were distributed to fetal tissues (Schechter & Roth, 1971). In rhesus monkeys, cyclamate crossed the placenta ( Pitkin et al. , 1969 ).
Here's the lowdown on sugar substitutes, artificial sweeteners, and natural sweeteners during pregnancy, including which ones are considered safe and which sweeteners to avoid when you're pregnant.
Most low-calorie sweeteners that the FDA has approved or recognized as safe are OK to use in moderation during pregnancy. Scientists are still studying their effects on children and pregnant women. But to date, many studies have shown them to generally be safe in small quantities, even during pregnancy.
