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1. www.cancer.gov › about-cancer › causes-preventionArtificial Sweeteners and Cancer - NCI - National Cancer...

   www.cancer.gov › about-cancer › causes-prevention

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   Concerns about artificial sweeteners and cancer initially arose when early studies linked the combination of cyclamate plus saccharin (and, to a lesser extent, cyclamate alone) with the development of bladder cancer in laboratory animals, particularly male rats.

   • Obesity and Cancer

     Obesity is a disease in which a person has an unhealthy...

   • Gastrointestinal Tract

     The organs that food and liquids travel through when they...

   • Calories

     NCI's Dictionary of Cancer Terms provides easy-to-understand...

   • Diabetes

     Any of several diseases in which the kidneys make a large...

   • Animal Studies

     A laboratory experiment using animals to study the...

   • Lymphoma

     Cancer that begins in cells of the immune system. There are...

   • World Health Organization

     A part of the United Nations that deals with major health...

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     Cancer that forms in tissues of the kidneys. There are many...

2. pmc.ncbi.nlm.nih.gov › articles › PMC10146554Impact of Long-Term Cyclamate and Saccharin Consumption on...

   pmc.ncbi.nlm.nih.gov › articles › PMC10146554

   No previous study has described the effects of chronic consumption of the cyclamate and saccharin combination on oxidative stress, lipid profile, glycemic control, creatinine, and alanine transaminase activity in healthy individuals and in patients with type 2 diabetes mellitus (T2DM).

3. academic.oup.com › toxsci › articleLong-Term Toxicity and Carcinogenicity Study of Cyclamate in...

   academic.oup.com › toxsci › article

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   1 sty 2000 · One case of early prostate cancer and two cases of benign tumors (thyroid adenoma and uterine leiomyoma) were found in the 100 mg/kg cyclamate group. Two cases of metastatic cancer (one colon carcinoma and one hepatocellular carcinoma) and one case of a leiomyoma were diagnosed in 24-year-old monkeys in the 500 mg/kg cyclamate group.

4. www.annalsofoncology.org › article › S0923-7534(19)51037-7Artificial sweeteners—do they bear a carcinogenic risk?

   www.annalsofoncology.org › article › S0923-7534(19)51037-7

   Epidemiological studies in humans did not find the bladder cancer-inducing effects of saccharin and cyclamate that had been reported from animal studies in rats. Despite some rather unscientific assumptions, there is no evidence that aspartame is carcinogenic.

5. www.sciencedirect.com › sodium-cyclamateSodium Cyclamate - an overview | ScienceDirect Topics

   www.sciencedirect.com › sodium-cyclamate

   Cyclamates. Sodium cyclamate is a potent sweetening agent. It has been subjected to numerous safety and carcinogenicity studies. Animal data led to warning against excessive and indiscriminate use a long time ago, causing the World Health Organization in 1967 to adopt a safety limit of 50 mg/kg.

6. www.ncbi.nlm.nih.gov › pmc › articlesNon‐nutritive sweeteners for diabetes mellitus - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   27 lis 2017 · This leads to chronic hyperglycaemia (i.e. elevated plasma glucose levels) and disturbances of carbohydrate, fat, and protein metabolism. In the long term, this condition leads to complications such as retinopathy, nephropathy, neuropathy, and an increased risk for cardiovascular diseases.

7. www.europarl.europa.eu › doceo › documentCyclamate in food poses a danger to our health - European...

   www.europarl.europa.eu › doceo › document

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   Cyclamate is an artificial sweetener (code E952) with a high sweetening power; according to numerous studies, in some people it can lead to the formation of a substance (CHA) which, when given in significant doses in animal testing, resulted in testicular damage.