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Sodium cyclamate was tested for carcinogenicity both alone and in combination with other chemicals in different animal species and by several routes of administration. Following its oral administration to two strains of mice, an increased incidence of lymphosarcomas was observed in female mice of one strain; a few bladder tumours were seen in ...
The FDA, initially the enabler of the cyclamate revolution, found itself in an ironic twist of fate: they were now the bearers of bad news. In a move that stunned the industry and the public alike, the FDA rescinded its approval of cyclamates in 1969, citing concerns over potential health risks.
In cultured bladders from young female Fischer 344 rats, 12 or 24 mmol/L sodium cyclamate produced pronounced urethelial hyperplasia and dysplasia, as confirmed by histology (Knowles et al., 1986).
Cyclamate is an artificial sweetener. It is 30–50 times sweeter than sucrose (table sugar), making it the least potent of the commercially used artificial sweeteners. It is often used with other artificial sweeteners, especially saccharin; the mixture of 10 parts cyclamate to 1 part saccharin is common and masks the off-tastes of both ...
9 kwi 2022 · Sodium cyclamate and cyclohexylamine (CHA) are associated with health effects of potential concern; however, at levels of exposure considered in the assessment, the Government concluded that these substances are not harmful to human health or the environment.
Cyclamate, odorless white crystalline powder that is used as a nonnutritive sweetener. The name usually denotes either calcium cyclamate or sodium cyclamate. Although they commonly are used as sweeteners in foods and beverages, cyclamates are banned in some places because of safety concerns.
Whether cyclamate has adverse side effects on humans is controversial. Some studies have suggested that very high doses of cyclamate may be associated with bladder cancer or testicular atrophy in some animals, and the U.S. Food and Drug Administration has banned cyclamate from food products.
