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The relative risk for bladder cancer associated with use of artificial sweeteners was 1.0 (95% confidence interval, 0.89–1.1) among men and 1.1 (0.89–1.3) among women. Significant trends of increasing risk with increasing average daily consumption were found in certain subgroups examined a priori on the basis of the results of animal ...
No previous study has described the effects of chronic consumption of the cyclamate and saccharin combination on oxidative stress, lipid profile, glycemic control, creatinine, and alanine transaminase activity in healthy individuals and in patients with type 2 diabetes mellitus (T2DM).
Dominant lethal mutations were not induced in male and female mice fed a diet containing sodium cyclamate for 10 weeks or in male mice treated orally for five days or female mice dosed once. Sperm morphology was unaffected in mice treated by intraperitoneal injection on five consecutive days with sodium cyclamate.
The JECFA set an ADI for cyclamate at 11 mg kg − 1 body weight per day. Cyclamates were banned by the FDA as a food ingredient in 1969 because the saccharin/cyclamate mixture was shown to cause cancer in experimental laboratory rats.
Concerns about artificial sweeteners and cancer initially arose when early studies linked the combination of cyclamate plus saccharin (and, to a lesser extent, cyclamate alone) with the development of bladder cancer in laboratory animals, particularly male rats.
The Scientific Committee for Food (SCF) reviewed the toxicity of cyclamate, cyclohexylamine and dicyclohexylamine in 1985 and established a temporary ADI of 0-11 mg/kg bodyweight (bw), expressed as cyclamic acid, for cyclamic acid and its sodium and calcium salts (1).
Cyclamates. Sodium cyclamate is a potent sweetening agent. It has been subjected to numerous safety and carcinogenicity studies. Animal data led to warning against excessive and indiscriminate use a long time ago, causing the World Health Organization in 1967 to adopt a safety limit of 50 mg/kg.
