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The relative risk for bladder cancer associated with use of artificial sweeteners was 1.0 (95% confidence interval, 0.89–1.1) among men and 1.1 (0.89–1.3) among women. Significant trends of increasing risk with increasing average daily consumption were found in certain subgroups examined a priori on the basis of the results of animal ...
The mean intake (expressed as percentage of the ADI of 11 mg/kg bw) of cyclamates was 23% by all consumers 12–39 years of age (men, 27%; women, 21%), 34% by all consumers 12–17 years of age, 20% by all consumers 18–24 years of age and 20% by all consumers 25–39 years of age (National Food Authority, 1995).
In a study in the USA of bladder cancer in women aged 20-49, the odds ratio for regular use of artificially sweetened beverages, table-top sweetener or both was 1.1 (0.7-1.7) [ref: 15]. In Canada, the odds ratio for use of cyclamate was 1.09 (0.60-1.97) in males and 0.92 (0.63-1.36) in females.
4 sty 2014 · The Norwegian Scientific Committee for Food Safety (VKM) has at the request of the Norwegian Food Safety Authority conducted a risk assessment of the intense sweeteners cyclamate, saccharin, neohesperidine DC, steviol glycosides and neotame from soft drinks, “saft” and nectar.
cyclamate intake was calculated from the reported intakes of foods and the sweetener content, obtained from the respective manufacturers. 18% of the population consumed cyclamate (21% in males, 15.4% in females), the highest percentage of 33% consumers was found in men aged 35-44 years.
Cyclamates. Sodium cyclamate is a potent sweetening agent. It has been subjected to numerous safety and carcinogenicity studies. Animal data led to warning against excessive and indiscriminate use a long time ago, causing the World Health Organization in 1967 to adopt a safety limit of 50 mg/kg.
Studies of saccharin and cyclamate use with smoking habits have shown no consistent interaction with heavy smoking, as might be expected from a promotional effect. In some studies, however, an increased risk with saccharin and cyclamate use has been observed in female non-smokers--a group otherwise at low risk for bladder cancer.
