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The relative risk for bladder cancer associated with use of artificial sweeteners was 1.0 (95% confidence interval, 0.89–1.1) among men and 1.1 (0.89–1.3) among women. Significant trends of increasing risk with increasing average daily consumption were found in certain subgroups examined a priori on the basis of the results of animal ...
The oral LD 50 of sodium cyclamate in mice and rats is 10–12 g/kg bw (Richards et al., 1951); the oral LD 50 in male and female hamsters—based on eight days’ administration in drinking-water and calculated on the basis of mortality up to day 16—was 9.8 and 12 g/kg bw, respectively; for calcium cyclamate, the respective values were 4.5 ...
Most studies of the other approved artificial sweeteners have provided no evidence that they cause cancer or other adverse health effects in lab animals. Cyclamate. As a result of the findings of early studies of cyclamate, it was banned in the United States in 1969.
Several low-calorie synthetic sweeteners have recently emerged in the pharmaceutical and food industries, but their health risks due to their side effects restrict their adoption [4,5]. Several previous studies have shown that the use of artificial sweeteners can be hazardous to human health [ 6 , 7 ].
Cyclamates. Sodium cyclamate is a potent sweetening agent. It has been subjected to numerous safety and carcinogenicity studies. Animal data led to warning against excessive and indiscriminate use a long time ago, causing the World Health Organization in 1967 to adopt a safety limit of 50 mg/kg.
Studies of saccharin and cyclamate use with smoking habits have shown no consistent interaction with heavy smoking, as might be expected from a promotional effect. In some studies, however, an increased risk with saccharin and cyclamate use has been observed in female non-smokers--a group otherwise at low risk for bladder cancer.
Cyclamate is an artificial sweetener (code E952) with a high sweetening power; according to numerous studies, in some people it can lead to the formation of a substance (CHA) which, when given in significant doses in animal testing, resulted in testicular damage.
