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24 kwi 2019 · Sensitivities for cancer were 46.1% for CRP, 43.6% ESR and 49.7% for PV. Cancer should be considered in patients with raised inflammatory markers.
We studied the correlation between CRP and corticosteroid doses in RA patients, fulfilling the American Rheumatism Association 1987 criteria, treated with oral steroids, disease-modifying anti-rheumatic drugs, and cyclooxygenase-2 selective inhibitors.
Our study found that patients who received corticosteroids presented differences in the systemic anti-inflammatory effect as measured by CRP at day 3, with variations related to the presence or absence of lymphopenia.
Results: 2,069 patients had CRP and ESR measured on the same day; 87 had discordant results, 55 (2.6%) with elevated ESR/low CRP, 32 (1.5%) with elevated CRP/ low ESR. Underlying infection was associated with > 14 fold risk of elevated ESR/low CRP discordance (p < 0.001).
A significant correlation between ESR and CRP was found (ESR after 1 h/CRP: correlation coefficient 0.6944, ESR after 2 h/CRP: correlation coefficient 0.6126). There was no difference in ESR or CRP between male and female patients, and patients older than 40 years had higher ESR and CRP.
Seventy-two (4.8%) participants showed a discordant pattern of high ESR and normal CRP values, which was associated with age after adjusting for sex, alcohol consumption, physical activity, BMI, and the presence of metabolic syndrome (odds ratio [OR], 1.052; 95% CI, 1.034–1.071; P < .001).
Agreement between ESR and CRP was observed in 67% of patients (37% of patients had normal results for both and 30% had elevated markers for both). There were some discordant results—28% of patients had increased ESR and normal CRP, and 5% of patients had normal ESR and elevated CRP.
