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C-reactive protein (CRP) is an annular (ring-shaped) pentameric protein found in blood plasma, whose circulating concentrations rise in response to inflammation. It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells.
10 lip 2023 · CRP is a pentameric protein synthesized by the liver, whose level rises in response to inflammation. CRP is an acute-phase reactant protein that is primarily induced by the IL-6 action on the gene responsible for the transcription of CRP during the acute phase of an inflammatory/infectious process.
1 sie 2001 · C-reactive protein (CRP) is an acute-phase protein featuring a homopentameric structure and Ca-binding specificity for phosphocholine (PCh). Expression of CRP is regulated mainly at the transcriptional level with interleukin-6 being the principal inducer of the gene during the acute phase.
13 cze 2024 · C-reactive protein (CRP) is a plasma protein that is evolutionarily conserved, found in both vertebrates and many invertebrates. It is a member of the pentraxin superfamily, characterized by its pentameric structure and calcium-dependent binding to ligands like phosphocholine (PC).
16 gru 2014 · Molecular structure of C-reactive protein (CRP). (a) Tape diagram of CRP, in which the 2 Ca 2+ atoms are presented (spheres). These are necessary for ligand binding. (b) Space model of CRP, with a phosphocholine molecule in the ligand binding site. (c) Nonglycosylated polypeptide subunit of monomeric C-reactive protein.
Protein Structure. CRP consists of five identical, noncovalently associated ∼23-kDa protomers arranged symmetrically around a central pore. The term “pentraxins” has been used to describe the family of related proteins with this structure.
Introduction. C-reactive protein (CRP) is a normal plasma protein, the circulating concentration of which rises dramatically in a cytokine-mediated response to most forms of tissue injury, infection and inflammation, and serum CRP values are widely measured in clinical practice as an objective index of disease activity [1,2].
