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12 mar 2022 · Two classes of anabolic drugs are now available to stimulate bone formation. Teriparatide and abaloparatide both target the parathyroid hormone-1 receptor, and are given by daily subcutaneous injection for up to 2 years. Romosozumab is an anti-sclerostin monoclonal antibody that stimulates bone formation and inhibits resorption.
11 sie 2024 · Currently, menaquinone is a second-line drug for the treatment of postmenopausal osteoporosis, and its efficacy in combination with bisphosphonates for the treatment of fractures in women with postmenopausal osteoporosis needs to be further explored.
In appropriate patients, treatment with effective antifracture medication prevents fractures and improves outcomes. Primary care providers and medical specialists are critical gatekeepers who can identify fractures and initiate proven osteoporosis interventions.
27 gru 2022 · Raloxifene (Evista™) is Food and Drug Administration (FDA) approved for the prevention and treatment of osteoporosis. Raloxifene was also approved by the FDA in 2007 for reduction in the risk of invasive breast cancer in post-menopausal women with osteoporosis and postmenopausal women at high risk for invasive breast cancer.
28 kwi 2022 · In appropriate patients, treatment with effective antifracture medication prevents fractures and improves outcomes. Primary care providers and medical specialists are critical gatekeepers who can identify fractures and initiate proven osteoporosis interventions.
9 maj 2019 · In our analysis, COX-2 inhibitors were associated with an increased risk of upper gastrointestinal AEs, especially abdominal pain. We also found an increased risk of cardiovascular AEs with COX-2 inhibitors, namely hypertension, heart failure and edema.
Dual-energy X-ray absorptiometry is the most widely used, validated technique for measuring bone mineral density (BMD) and diagnosing osteoporosis. Cost-effectiveness analyses support early detection and treatment of high-risk patients with antiresorptive medications such as bisphosphonates.
