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4 lut 2021 · Association of aspirin use with incident dementia or mild cognitive decline in cohort studies. However, after adjusting for low-dose aspirin, the results showed a protective effect against the risk of dementia and MCI (the pooled RR = 0.75; 95% CI = 0.63–0.9; I2for heterogeneity = 50.5%) (Figure 3).
Globally, the number of older population aged 60 years or over was 962 million in 2017 and will almost double to reach 2.1 billion by 2050.1,2 The rising geriatric population results in an exponential increase in incidence of neurodegenerative disorders such as dementia.3,4 Worldwide, the population of people living with dementia was estimated ...
4 wrz 2021 · Acetylcholinesterase inhibitors (AChEIs), or so-called anti-dementia medications, have been developed to delay the progression of neurocognitive disorders and to decrease healthcare needs. AChEIs have been widely prescribed in clinical practice for the treatment of Alzheimer's disease, which account for 70% of dementia.
22 sty 2021 · This review of studies investigating the long-term efficacy and safety of aspirin in people with dementia found four reports, all concentrating on AD dementia. For the primary outcome of MACE, there was no evidence identified.
People with dementia may have indications for aspirin prescription and clinicians are asked to balance the potential risks against benefits. This review examines the evidence for the risk and benefit of long-term aspirin use in people with dementia aged over 65 years, including randomised controlled trials and observational studies.
When describing users of the drugs, we required a minimum amount of use of one of the four drugs (specified below). In analyses of medication use among individuals with a diagnosis, we required individuals to have a diagnosis of AD, non-AD dementia, and/or dementia-related symptoms (defined below).
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