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16 wrz 2021 · We simulated changes in resistance to flow or absorption of CSF and cerebral ISF to model hydrocephalus, cerebral edema, and to simulate disruption of the blood–brain barrier (BBB).
28 lip 2021 · This matching requires continuous regulation of cerebral blood flow (CBF), which can be categorized into four broad topics: 1) autoregulation, which describes the response of the cerebrovasculature to changes in perfusion pressure; 2) vascular reactivity to vasoactive stimuli [including carbon dioxide (CO 2)]; 3) neurovascular coupling (NVC), i ...
18 lis 2020 · Across the endothelium, there is rapid free diffusion of oxygen from the blood to the brain and carbon dioxide diffusion in the opposite direction, which is essential for normal brain metabolism and regulation of pH in the brain ISF, neurons, and other NVU cells.
18 sty 2011 · The two barriers that represent the largest interface between blood and brain extracellular fluids, the BBB and the BCSFB, prevent the free paracellular diffusion of polar molecules by complex morphological features, including tight junctions (TJs) that interconnect the endothelial and epithelial cells, respectively.
The field of brain fluid transport encompasses CSF formation and flow pathways, ventricular morphology, brain extracellular space constitution, brain clearance, CSF drainage sites, and many other factors.
Transport across the blood-brain barrier is mediated by three energy-independent diffusion mechanisms and three energy-dependent transport mechanisms. The energy-independent mechanisms include transcellular diffusion, paracellular diffusion, and passive diffusion.
10 lis 2010 · Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these cells control blood flow is crucial for understanding how neural computation is powered, for...
